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MedTech Outlook | Thursday, May 26, 2022
The pipeline for wound healing technologies includes lasers that kill bacteria and fluorescence imaging to aid in diagnostics.
FREMONT, CA: A skin wound is typically considered to be of little concern to the average person; however, a variety of disorders can cause or contribute to the severity of a wound that necessitates the use of specific technologies for proper healing.
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Patients are predisposed to chronic wounds due to underlying factors ranging from malnutrition and stress to metabolic syndrome, necessitating intervention to accelerate a sluggish healing process.
In the United States, 3 percent of the population over the age of 65 has open wounds, and 2 percent of the entire population suffers from chronic wounds, according to a recent scholarly article that examined the magnitude of the problem.
Medicare cost forecasts for all wounds, including costs for infection treatment, range from $28.1 billion to $96.7 billion, with surgical wounds and diabetic ulcers being the most expensive to treat.
Medical practitioners already employ innovations such as biological dressings and negative pressure therapy for wound healing. Consider the role that many potential technologies may play in future therapeutic routes.
3D-printed stem cells
The well-documented ability of stem cells to transform into any cell type in the body provides the basis for several therapeutic uses, including faster wound healing.
However, in February of this year, a research team at the University of Toronto announced a portable 3D printer that can deposit stem cells into wounds implanted in a bioink-based skin graft to promote tissue recovery.
Uncertainty surrounds the technique's utility for chronic wounds, as the study supporting the device focused on full-thickness burns—those that affect all three layers of skin.
In contrast, an assessment of natural bioinks conducted in August of this year determined that they shown "outstanding ability" to simulate the three-dimensional microenvironment structure of original skin tissue and stimulate cell adhesion, proliferation, migration, and mobility.
Researchers anticipate that the portable 3D printer will be utilized in therapeutic settings over the next five years.
Collagen-based wound dressing
Before discussing the possibility of a skin graft, wounds are often covered with a dressing, and depending on the severity, maybe an advanced covering designed to promote healing.
However, despite the variety of materials utilized to create these dressings, current products cannot simultaneously build antibacterial barriers and promote rapid wound healing.
The recent discovery of the healing and antibacterial characteristics of human collagen VI has permitted the development of a product with the potential to enhance wound treatment.
Fluorescence point-of-care imaging
Instead of treating the wound directly, fluorescence point-of-care imaging is a diagnostic technique that enables doctors to obtain an accurate picture of the quantity and pathogenicity of bacteria to personalize treatment to the individual.
Recent research on 350 patients with diabetic foot ulcers revealed that using MolecuLight fluorescence point-of-care imaging enhanced the frequency of diabetic foot ulcer lesions that healed within 12 weeks by 23 percent.
Fluorescence imaging was associated with a 49 percent reduction in antimicrobial dressing prescriptions and a 33 percent reduction in antibiotic prescriptions.
MolecuLight's handheld, portable autofluorescence imaging device is CE-approved for sale and is currently available in Canada.
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